December 1, 2006Vascular Health and Risk ManagementOpen Access

Sildenafil in the treatment of pulmonary hypertension

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Why the study?

Does sildenafil improve hemodynamics and exercise tolerance in patients with pulmonary hypertension?

Population

Patients with pulmonary hypertension, including pulmonary arterial hypertension, adults, children, and…

Design

Review

Authors

CBChristopher F. BarnettUniversity of California, San Francisco RMRoberto F. MachadoUniversidade Federal de Juiz de Fora

Discussion

Member takes

Implication

May support sildenafil consideration in PAH; leaves open confirmation via prospective RCTs.

Structured PICO

Does sildenafil improve hemodynamics and exercise tolerance in patients with pulmonary hypertension?

Population

Patients with pulmonary hypertension, including pulmonary arterial hypertension, adults, children, and neonates after cardiac surgery, left heart failure, fibrotic pulmonary disease, high altitude exposure, and thromboembolic disease

Intervention

Sildenafil (phosphodiesterase type 5 inhibitor)

Outcome

Improvement in mean pulmonary artery pressure, pulmonary vascular resistance, cardiac index, and exercise tolerancesurrogate

Sildenafil is an effective and safe oral therapy for improving hemodynamics and exercise tolerance in selected patients with pulmonary hypertension.

Cite This Study

Barnett et al. (2006) studied this question.

synapsesocial.com/papers/69de4fabbf539e22705584ee https://doi.org/10.2147/vhrm.2006.2.4.411

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Sildenafil in the treatment of pulmonary hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sildenafil in the treatment of pulmonary hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider