January 1, 1995Diabetes
Gender and Insulin Sensitivity in the Heart and in Skeletal Muscles: Studies Using Positron Emission Tomography
Why the study?
Does insulin sensitivity of glucose uptake in heart and skeletal muscles differ between healthy women and men?
Population
Healthy women and men matched for age, BMI, and VO2max
Comparison
Measurement of insulin sensitivity of glucose… vs Men vs. Women
Design
Cross-sectional
Authors
Discussion
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Implication
Greater skeletal but equivalent cardiac insulin sensitivity in women vs men; hypothesis-generating for sex-specific cardiometabolic risk, needs prospective validation.
Structured PICO
Does insulin sensitivity of glucose uptake in heart and skeletal muscles differ between healthy women and men?
P
Population
Healthy women and men matched for age, BMI, and VO2max
I
Intervention
Measurement of insulin sensitivity of glucose uptake using [18F]fluoro-2-deoxy-D-glucose and positron emission tomography under hyperinsulinemic normoglycemic conditions
C
Comparator
Men vs. Women
O
Outcome
Insulin sensitivity of glucose uptake in muscle and heart tissuessurrogate
Healthy women have greater whole-body and skeletal muscle insulin sensitivity compared to equally fit men, but heart insulin sensitivity is similar between genders.
Cite This Study
Nuutila et al. (1995) studied this question.