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Randomized trial finds rapid antidepressant effects of ketamine in treatment-resistant depression, suggesting NMDA receptor modulation may be a promising approach.
Ketamine demonstrated rapid antidepressant effects in an optimized study design, further supporting NMDA receptor modulation as a novel mechanism for accelerated improvement in severe and chronic forms of depression. More information on response durability and safety is required before implementation in clinical practice.
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Murrough et al. (2013) studied this question.
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