Does chronic atrial ischemia/infarction promote substrates for atrial fibrillation in a canine model?
Chronic atrial ischemia/infarction in a canine model creates substrates for both spontaneous ectopy and sustained reentry, providing insights into AF mechanisms in patients with coronary artery disease.
Chronic atrial ischemia/infarction creates substrates for both spontaneous ectopy (Ca(2+)-release events, increased Na(+)-Ca(2+) exchange current) and sustained reentry (conduction abnormalities that anchor reentry). Thus, chronic atrial infarction in dogs promotes both AF triggers and the substrate for AF maintenance. These results provide novel insights into potential AF mechanisms in patients with coronary artery disease.
Nishida et al. (Tue,) studied this question.
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