Experimental study demonstrates efficient mechanochemical synthesis of carboxylic acids using gaseous carbon dioxide and minimal solvent, highlighting a sustainable Grignard protocol.
A one‐pot, three‐step protocol for the preparation of Grignard reagents from organobromides in a ball mill and their subsequent reactions with gaseous carbon dioxide (CO 2 ) or sodium methyl carbonate providing aryl and alkyl carboxylic acids in up to 82 % yield is reported. Noteworthy are the short reaction times and the significantly reduced solvent amounts [2.0 equiv. for liquid assisted grinding (LAG) conditions]. Unexpectedly, aryl bromides with methoxy substituents lead to symmetric ketones as major products.
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Pfennig et al. (2021) studied this question.
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