Why the study?
Guidelines suggest a 12-item score and a d-dimer cutoff of 500 ng/mL for suspected acute aortic syndromes, but a simplified score and more specific cutoff could be advantageous.
Does the simplified AORTAs score integrated with age-adjusted d-dimer improve diagnostic accuracy for acute aortic syndromes compared to the standard aortic dissection detection score?
Population
Patients with suspected AASs across a derivation cohort (n=1848) and two validation cohorts (n=1035 and n=447)
Comparison
Simplified AORTAs score with age-adjusted d-dimer vs aortic dissection detection score
Design
Derivation and validation cohort study
Follow-up
30-day follow-up in the prospective validation cohort
Authors
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May support sensitive rule-out of acute aortic syndromes; hypothesis-generating and should not yet change practice.
Does the simplified AORTAs score integrated with age-adjusted d-dimer improve diagnostic accuracy for acute aortic syndromes compared to the standard aortic dissection detection score?
The simplified AORTAs score integrated with age-adjusted d-dimer provides improved sensitivity and classification for diagnosing acute aortic syndromes compared to the standard ADD score.
Morello et al. (2021) studied this question.
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