Review identifies biases in combining diverse study designs, highlighting the need for refined methodologies.
For a full assessment of risk factors with a high prevalence in the general population, pooling of data will become increasingly important. Future research needs to focus on the deficiencies of review methods, in particular, the errors and biases that can be produced when studies are combined that have used different designs, methods and analytic models.
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M Blettner (1999) studied this question.
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