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Cross-sectional neuroimaging reveals reduced global brain GABA levels in unmedicated individuals with primary insomnia, indicating a distinct neurochemical pathology underlying sleep disruption.
Our preliminary finding of a global reduction in GABA in non-medicated individuals with PI is the first demonstration of a neurochemical difference in the brains of those with PI compared to normal sleeping controls. 1H-MRS is a valuable tool to assess GABA in vivo, and may provide a means to shed further light on the neurobiology of insomnia.
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Winkelman et al. (2008) studied this question.
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