What question did this study set out to answer?

Determine whether antibiotic prescriptions during early life are associated with asthma exacerbations, reduced antiviral immunity, and 17q21 genetic variants.

May 14, 2014The Lancet Respiratory MedicineOpen Access

Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study

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Determine whether antibiotic prescriptions during early life are associated with asthma exacerbations, reduced antiviral immunity, and 17q21 genetic variants.
Conducted a population-based birth cohort study tracking early childhood antibiotic prescription data.
Evaluated subsequent asthma exacerbations, antiviral immune function, and genetic variation at chromosome 17q21.
Identifies an association between early antibiotic exposure and increased asthma exacerbation rates alongside impaired antiviral immune responses.
Demonstrates significant interaction between early life antibiotic exposure and specific genetic variants located at chromosome 17q21.

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Implication

Cohort study uncovers links between early antibiotic prescriptions and asthma exacerbations in children, suggesting critical genetic interactions.

Abstract

Moulton Charitable Foundation and Medical Research Council.

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Cite This Study

Semic‐Jusufagic et al. (2014) studied this question.

synapsesocial.com/papers/69de66e6681d8c8a46e93d3b https://doi.org/10.1016/s2213-2600(14)70096-7

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Implication

Cohort study uncovers links between early antibiotic prescriptions and asthma exacerbations in children, suggesting critical genetic interactions.

Abstract

Moulton Charitable Foundation and Medical Research Council.

Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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