Meta-analysis reveals cerebrospinal fluid neurofilament light chain correlates with multiple sclerosis relapses, indicating its utility primarily as a marker of acute disease activity.
CSF NfL correlates with MS activity throughout the course of MS, reflecting the axonal damage in pwMS. Relapse is more strongly associated with elevated CSF NfL levels than the development of progression, and NfL may be most useful as a marker of disease 'activity' rather than as a marker of disability or disease stage.
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Martin et al. (2019) studied this question.
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