Novel phenoxyalkylamine derivatives. II. Synthesis and Ca2+-antagonistic activities of .ALPHA.-alkyl-.ALPHA.-((phenoxypropylamino)propyl)-benzeneacetonitrile derivatives.

α-Alkyl-α-(phenoxypropylamino)propylbenzeneacetonitrile derivatives containing various substituents on the ring of the benzeneacetonitrile moiety (A), the quaternary carbon atom and the ring of the phenoxy moiety (B) were prepared, and their Ca2+-antagonistic activities were evaluated. Among these compounds, the N-Me derivatives with a 3, 4, 5-(OMe)3 group on the A ring, an iso-Pr group on the quaternary carbon atom, and a m-OMe, 3, 5-(OMe)2, 3, 5-Me2 or 3, 4, 5-(OMe)3 group on the B ring were found to possess Ca2+-antagonistic activity higher than pA2=9. The effects of substitutions at the A ring, the quaternary carbon atom and the B ring are discussed.