Observational analysis demonstrates alterations in gut microbiota structure and immune balance in seniors and centenarians, suggesting links to frailty and disease.
We provide evidence for the fact that the ageing process deeply affects the structure of the human gut microbiota, as well as its homeostasis with the host's immune system. Because of its crucial role in the host physiology and health status, age-related differences in the gut microbiota composition may be related to the progression of diseases and frailty in the elderly population.
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Biagi et al. (2010) studied this question.
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