Active sonic hedgehog signaling between androgen independent human prostate cancer cells and normal/benign but not cancer‐associated prostate stromal cells

Based on co-culture and chimeric tumor models, active Shh-mediated signaling was demonstrated between AI prostate cancer and NPF in a paracrine- and tumor progression-dependent manner. Our study suggests that drugs like cyclopamine that interfere with Shh signaling could be beneficial in preventing AI progression in prostate cancer cells.