What question did this study set out to answer?

To assess whether international disparities in hemodialysis mortality rates are explained by variations in patient demographics and comorbid conditions across regions.

December 1, 2003Journal of the American Society of Nephrology

Association of Comorbid Conditions and Mortality in Hemodialysis Patients in Europe, Japan, and the United States

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Authors

DGDavid A. GoodkinBellevue College JBJennifer L. Bragg‐GreshamCross-Cutting Cardiology KKKarl KoenigAmgen (United States)

Discussion

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Implication

Prospective observational study reveals major international mortality differences in hemodialysis patients, indicating that case-mix variations do not fully explain regional survival gaps.

Key Points

To assess whether international disparities in hemodialysis mortality rates are explained by variations in patient demographics and comorbid conditions across regions.
Prospective, observational study (Dialysis Outcomes and Practice Patterns Study) analyzing 16,720 hemodialysis patients followed for up to 5 years across France, Germany, Italy, Japan, Spain, the United Kingdom, and the United States.
Tracked patient demographics, prescriptions, laboratory values, facility practice patterns, and 25 comorbid conditions to determine their relationship with patient survival.
Crude 1-year mortality rates were 6.6% in Japan, 15.6% in Europe, and 21.7% in the United States.
Following adjustment for age, sex, race, and 25 comorbidities, mortality risk was elevated in Europe (RR 2.84, P < 0.0001) and the US (RR 3.78, P < 0.0001) compared to Japan, and higher in the US than Europe (RR 1.33, P < 0.0001).
Older age and comorbidities were associated with increased mortality risk, except hypertension, which was associated with reduced mortality (multivariate RR 0.74, P < 0.0001).

Cite This Study

Goodkin et al. (2003) studied this question.

synapsesocial.com/papers/69de71fe57c7c8340a55878d https://doi.org/10.1097/01.asn.0000100127.54107.57

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December 1, 2003Journal of the American Society of Nephrology

Association of Comorbid Conditions and Mortality in Hemodialysis Patients in Europe, Japan, and the United States

View Full Paper

Ask AI

Bookmark

Authors

DGDavid A. GoodkinBellevue College JBJennifer L. Bragg‐GreshamCross-Cutting Cardiology KKKarl KoenigAmgen (United States)

Discussion

Member takes

Implication

Prospective observational study reveals major international mortality differences in hemodialysis patients, indicating that case-mix variations do not fully explain regional survival gaps.

Key Points

To assess whether international disparities in hemodialysis mortality rates are explained by variations in patient demographics and comorbid conditions across regions.
Prospective, observational study (Dialysis Outcomes and Practice Patterns Study) analyzing 16,720 hemodialysis patients followed for up to 5 years across France, Germany, Italy, Japan, Spain, the United Kingdom, and the United States.
Tracked patient demographics, prescriptions, laboratory values, facility practice patterns, and 25 comorbid conditions to determine their relationship with patient survival.
Crude 1-year mortality rates were 6.6% in Japan, 15.6% in Europe, and 21.7% in the United States.
Following adjustment for age, sex, race, and 25 comorbidities, mortality risk was elevated in Europe (RR 2.84, P < 0.0001) and the US (RR 3.78, P < 0.0001) compared to Japan, and higher in the US than Europe (RR 1.33, P < 0.0001).
Older age and comorbidities were associated with increased mortality risk, except hypertension, which was associated with reduced mortality (multivariate RR 0.74, P < 0.0001).

Cite This Study

Goodkin et al. (2003) studied this question.

synapsesocial.com/papers/69de71fe57c7c8340a55878d https://doi.org/10.1097/01.asn.0000100127.54107.57

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