Population
Cultured neonatal rat ventricular cardiocytes (model of cardiac hypertrophy)
Comparison
Stimulation with endothelin-1, phenylephrine, or… vs Comparison with atrial natriuretic peptide gene…
Design
Preclinical
Authors
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Rapid BNP activation in hypertrophy is hypothesis-generating; leaves open validation as emergency hormone in human overload.
BNP gene expression is rapidly activated and turned over during cardiocyte hypertrophy, supporting its role as an emergency cardiac hormone against ventricular overload.
Nakagawa et al. (1995) studied this question.
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