April 1, 1991Journal of Biological ChemistryOpen Access

Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression.

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Population

Neonatal rat ventricular cells

Design

Preclinical

Authors

KKKirk U. KnowltonHeart Failure & Transplant EBE. BaracchiniScripps Research Institute RRRobert S. RossPurbanchal University

Discussion

Member takes

Implication

Remains preclinical in animal myocytes; leaves open whether alpha-adrenergic cis-regulation drives human cardiac hypertrophy.

Structured PICO

Population

Neonatal rat ventricular cells

Intervention

Alpha-adrenergic stimulation (treatment with alpha-adrenergic agonists)

Outcome

Expression levels of cardiac genes (ANF, MLC-2, and cardiac sodium channel) measured by mRNA levels and luciferase reporter activitysurrogate

Alpha-adrenergic stimulation selectively induces specific cardiac genes (ANF, MLC-2) via distinct cis-regulatory sequences, providing insight into gene regulation during cardiac myocyte hypertrophy.

Cite This Study

Knowlton et al. (1991) studied this question.

synapsesocial.com/papers/69de72fcfd84e72eb2558557 https://doi.org/10.1016/s0021-9258(20)89515-5

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Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider