What question did this study set out to answer?

To determine whether restricting intravenous fluid administration reduces 90-day mortality compared to standard intravenous fluid therapy in adult intensive care unit patients with septic shock.

June 17, 2022New England Journal of MedicineOpen Access

Restriction of Intravenous Fluid in ICU Patients with Septic Shock

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Authors

TMTine Sylvest Meyhoff PHPeter Buhl Hjortrup JWJørn Wetterslev

Discussion

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Overview

Randomized trial shows restrictive intravenous fluids do not reduce 90-day mortality in ICU septic shock patients, indicating standard fluid therapy remains a reasonable clinical approach.

Key Points

To determine whether restricting intravenous fluid administration reduces 90-day mortality compared to standard intravenous fluid therapy in adult intensive care unit patients with septic shock.
Randomized clinical trial (CLASSIC trial, ClinicalTrials.gov number NCT03668236) comparing restrictive versus standard intravenous fluid administration.
Conducted in adult intensive care unit patients presenting with septic shock, evaluating all-cause mortality at 90 days.
Intravenous fluid restriction did not result in fewer deaths at 90 days compared with standard intravenous fluid therapy.
Per-arm event rates, effect sizes, and exact p-values were not reported in the abstract.

Cite This Study

Meyhoff et al. (2022) studied this question.

synapsesocial.com/papers/69de79c8da08968cf7b0c3b3 https://doi.org/10.1056/nejmoa2202707

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June 17, 2022New England Journal of MedicineOpen Access

Restriction of Intravenous Fluid in ICU Patients with Septic Shock

View Full Paper

Ask AI

Bookmark

Authors

TMTine Sylvest Meyhoff PHPeter Buhl Hjortrup JWJørn Wetterslev

Discussion

Member takes

Overview

Randomized trial shows restrictive intravenous fluids do not reduce 90-day mortality in ICU septic shock patients, indicating standard fluid therapy remains a reasonable clinical approach.

Key Points

To determine whether restricting intravenous fluid administration reduces 90-day mortality compared to standard intravenous fluid therapy in adult intensive care unit patients with septic shock.
Randomized clinical trial (CLASSIC trial, ClinicalTrials.gov number NCT03668236) comparing restrictive versus standard intravenous fluid administration.
Conducted in adult intensive care unit patients presenting with septic shock, evaluating all-cause mortality at 90 days.
Intravenous fluid restriction did not result in fewer deaths at 90 days compared with standard intravenous fluid therapy.
Per-arm event rates, effect sizes, and exact p-values were not reported in the abstract.

Cite This Study

Meyhoff et al. (2022) studied this question.

synapsesocial.com/papers/69de79c8da08968cf7b0c3b3 https://doi.org/10.1056/nejmoa2202707

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