Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma
To characterize the relationship between gut microbiome alterations and the serum metabolome for detecting colorectal cancer and precancerous adenomas.
Performed integrated multi-omic profiling combining fecal metagenomic sequencing and serum metabolomic analyses.
Demonstrated that gut microbiome reprogramming in colorectal cancer is linked to systemic alterations in the serum metabolome.
Identified gut microbiome-associated serum metabolites (GMSMs) as viable candidate biomarkers for the detection of colorectal cancer and adenomas.
Abstract
Gut microbiome reprogramming in patients with CRC is associated with alterations of the serum metabolome, and GMSMs have potential applications for CRC and adenoma detection.