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March 25, 2026Journal of Cancer PreventionOpen Access

Insights into the Relevance of the Interaction between Colorectal Cancer and Gut Microbiota-Derived Metabolites

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Authors

EKEun-Ju KimSHSun‐Young HwangKNKyoungok No

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Overview

This review explores metabolite interactions influencing colorectal cancer, suggesting novel diagnostic and therapeutic approaches.

Key Points

  • This review aims to elucidate the role of gut microbiota-derived metabolites in colorectal cancer progression and diagnosis.
  • Review of evidence on gut microbiota changes in colorectal cancer.
  • Analysis of metabolomic disturbances and microbial signatures.
  • Evaluation of biomarkers with high AUC values for cancer prediction.
  • Discussion on dietary phytochemicals' influence on inflammation and microbiota balance.
  • Increases in pathogenic bacteria like Escherichia coli and Enterococcus faecalis were noted.
  • Decreased levels of beneficial microbes, such as Akkermansia muciniphila, were observed.
  • Biomarkers showed high diagnostic accuracy with AUC values between 0.80 and 0.93.
  • Phytochemicals like resveratrol and curcumin can reduce colorectal cancer risk by modulating inflammatory pathways.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69c37aa8b34aaaeb1a67c8fchttps://doi.org/10.15430/jcp.25.057
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gut microbial metabolites in colorectal cancer: dual roles in tumorigenesis, immune crosstalk, and therapeutic innovation2026 · 1 citations
  2. 2Metabolic interactions: how gut microbial metabolites influence colorectal cancer2025 · 30 citations
  3. 3Microbiomics: Novel Biomarkers of Colorectal Cancer Diagnosis and Prognosis2026 · 1 citations
  4. 4Gut microbiota alterations and their association with tumorigenic pathways in colorectal cancer: insights from a pooled analysis of 109 microbiome datasets2025 · 2 citations
  5. 5Gut Microbiota in Colorectal Cancer: Mechanisms of Carcinogenesis, Biomarkers, and Therapeutic Perspectives2026