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May 24, 2026DiagnosticsOpen Access

Microbiomics: Novel Biomarkers of Colorectal Cancer Diagnosis and Prognosis

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Authors

LYLielong YangSichuan UniversityWMWenjian MengSichuan UniversityTYTinghan YangSichuan University

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Implication

Narrative review uncovers microbiome-based biomarkers for colorectal cancer diagnosis and prognosis, suggesting transformative implications for treatment.

Key Points

  • This review aims to identify and evaluate the potential of gut microbiome markers in colorectal cancer diagnosis and prognosis.
  • Reviewed current evidence on intestinal microorganisms and metabolic products as candidate biomarkers for colorectal cancer.
  • Discussed the role of specific gut bacteria in tumorigenesis and their associated mechanisms like immune modulation and inflammation.
  • Presented established and innovative detection strategies for microbiome profiling, including 16S rRNA sequencing and gene arrays.
  • Fusobacterium nucleatum correlates with advanced tumor stages, achieving high sensitivity combined with colibactin-producing E. coli for early-stage screening.
  • Akkermansia muciniphila levels can predict the effectiveness of PD-1 blockade immunotherapy.
  • Microbiota-derived indicators could innovate clinical practices in oncology, pending further validation and standardization.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a1296d548a0ea1665673f13https://doi.org/10.3390/diagnostics16111582
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Also Consider

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  1. 1European cancer mortality predictions for the year 2024 with focus on colorectal cancer2024 · 127 citations
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  4. 4Gut Microbiota in Colorectal Cancer: Associations, Mechanisms, and Clinical Approaches2021 · 15 citations
  5. 5Colibactin‐positive Escherichia coli induce a procarcinogenic immune environment leading to immunotherapy resistance in colorectal cancer2020 · 120 citations