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July 10, 2026Journal of Clinical MedicineOpen Access

Gut Microbiota in Colorectal Cancer: Mechanisms of Carcinogenesis, Biomarkers, and Therapeutic Perspectives

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Authors

BCBianca Andreea CristinescuLucian Blaga University of SibiuHDHorațiu DuraLucian Blaga University of SibiuRFRadu FleacăLucian Blaga University of Sibiu

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Overview

This review uncovers mechanisms and potential biomarkers of colorectal cancer from gut microbiota, indicating new diagnostic approaches.

Key Points

  • The aim is to explore the role of gut microbiota in colorectal cancer development and identify potential biomarkers for detection.
  • Review of existing literature on gut microbiota and colorectal cancer
  • Assessment of specific bacterial species as biomarkers
  • Analysis of microbial metabolites implicated in carcinogenesis.
  • Fusobacterium nucleatum shows promise as a non-invasive stool-based CRC detection biomarker.
  • Streptococcus gallolyticus and Clostridium septicum serve as clinical warning markers for colorectal malignancy.
  • Other microbial species, including pks+Escherichia coli and enterotoxigenic Bacteroides fragilis, remain investigational.

Cite This Study

Cristinescu et al. (2026) studied this question.

synapsesocial.com/papers/6a508c2d6eeac72a437a06c5https://doi.org/10.3390/jcm15145331
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