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This review explores the dual roles of gut microbial metabolites in colorectal cancer development and progression.

Gut microbial metabolites in colorectal cancer: dual roles in tumorigenesis, immune crosstalk, and therapeutic innovation

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Review reveals gut microbial metabolites influence tumor growth in colorectal cancer, indicating potential therapeutic targets.

This review explores the dual roles of gut microbial metabolites in colorectal cancer development and progression.
Systematic review of existing literature on gut microbial metabolites and colorectal cancer.
Analysis of the impact of microbial metabolites on tumor suppression and promotion in CRC.
Identification of barriers to clinical translation of metabolite-targeted therapies.
Microbial metabolites can suppress tumor growth by enhancing gut barrier integrity and reducing inflammation.
Under dysbiotic conditions, these metabolites may promote colorectal cancer through inflammatory cytokine release and DNA damage.
Highlighting potential for metabolite-targeted therapies while noting challenges like metabolite instability.

Jin et al. (2026) studied this question.

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