What question did this study set out to answer?

To determine how commensal microbiota composition influences respiratory mucosal immune responses and protection against influenza A virus infection.

March 14, 2011Proceedings of the National Academy of SciencesOpen Access

Microbiota regulates immune defense against respiratory tract influenza A virus infection

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Authors

TITakeshi IchinoheNational Institute of Infectious Diseases IPIris K. PangYale University YKYosuke KumamotoRutgers, The State University of New Jersey

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Implication

Experimental animal study reveals that commensal bacteria prime respiratory immune defenses against influenza A in mice, highlighting mucosal microbiota's role in lung antiviral responses.

Key Points

To determine how commensal microbiota composition influences respiratory mucosal immune responses and protection against influenza A virus infection.
Treated mice with various antibiotic regimens to selectively deplete specific bacterial populations, including neomycin-sensitive commensals, prior to respiratory influenza A challenge.
Administered local or distal Toll-like receptor (TLR) ligands to antibiotic-treated mice to test for rescue of impaired immune pathways.
Evaluated steady-state pro-IL-1β and pro-IL-18 expression, dendritic cell migration from the lungs to draining lymph nodes, and subsequent CD4, CD8, and antibody responses.
Depletion of neomycin-sensitive commensal bacteria impaired the generation of virus-specific CD4 T cells, CD8 T cells, and antibody responses following influenza infection.
Intact microbiota maintained steady-state expression of pro-IL-1β and pro-IL-18 mRNA, which enabled downstream inflammasome activation and dendritic cell migration to lymph nodes for proper T-cell priming.
Administration of local or systemic TLR ligands fully rescued the defective antiviral immune responses observed in antibiotic-treated mice.

Cite This Study

Ichinohe et al. (2011) studied this question.

synapsesocial.com/papers/69de7cb9bf539e2270558b82 https://doi.org/10.1073/pnas.1019378108

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Implication

Experimental animal study reveals that commensal bacteria prime respiratory immune defenses against influenza A in mice, highlighting mucosal microbiota's role in lung antiviral responses.

Microbiota regulates immune defense against respiratory tract influenza A virus infection

Discussion

Member takes

Implication

Key Points

Cite This Study

Microbiota regulates immune defense against respiratory tract influenza A virus infection

Discussion

Member takes

Implication

Key Points

Cite This Study

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