Cyclooxygenase-2 Expression Is an Independent Predictor of Poor Prognosis in Colon Cancer
Key Points
- To determine whether cyclooxygenase-2 (COX-2) overexpression independently predicts survival in colon cancer patients and whether this prognostic relationship is modified by p53 status.
- Evaluated COX-2 expression and p53 status in colon cancer patients.
- Assessed patient survival outcomes relative to tumor biomarker expression profiles.
- COX-2 overexpression is associated with significantly worse survival outcomes in colon cancer patients.
- The adverse prognostic effect of elevated COX-2 expression on clinical outcomes is modified by p53 status.
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Discussion
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Implication
Prognostic study reveals worse survival in colon cancer patients with COX-2 overexpression, indicating that p53 status modifies clinical outcomes.
Cite This Study
Ogino et al. (2008) studied this question.