Chemical synthesis study demonstrates selective copper-catalyzed carbon-carbon bond cleavage of ketones, suggesting an efficient route to aromatic and acrylic acids.
A novel copper-catalyzed aerobic oxidative C(NOH)-C(alkyl) bond cleavage reaction of aryl/aralkyl/vinyl ketones for the synthesis of aromatic/acrylic acids is described. A series of ketones having aryl/aralkyl/vinyl at the one end and methyl to any higher alkyl at the other end can be selectively cleaved and converted into the corresponding acids via oxime intermediates.
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Sathyanarayana et al. (2015) studied this question.
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