Why the study?
Evaluating polygenic risk can identify additional venous thromboembolism risk not captured in commonly investigated genes for inherited thrombophilia.
Does oral contraceptive use increase the risk of venous thromboembolism in women, particularly those with high genetic predisposition?
Does oral contraceptive use increase the risk of venous thromboembolism in women, particularly those with high genetic predisposition?
Polygenic risk scores can identify women at high risk for venous thromboembolism when using oral contraceptives, suggesting a role for personalized contraceptive counseling.
Supports genetic risk stratification in contraceptive counseling; hypothesis-generating for personalized VTE prevention pending prospective validation.
Evaluating polygenic risk can identify additional venous thromboembolism risk that is not captured in the commonly investigated genes for inherited thrombophilia. Our results indicate that oral contraceptive use is associated with an increased risk for developing a venous thromboembolism, particularly among women with a high genetic predisposition, and that oral contraceptive use dramatically increases the risk thereof short after initiation of use, which decreases with continued use. This suggests that the polygenic risk score could be used to identify women who are at high risk for developing a venous thromboembolism and advise them on alternative methods of contraception.
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Faro et al. (2023) studied this question.
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