June 6, 2005Proceedings of the National Academy of Sciences
Gene transfer to human joints: Progress toward a gene therapy of arthritis
Why the study?
Does intraarticular transfer of IL-1Ra cDNA safely result in transgene expression in postmenopausal women with advanced rheumatoid arthritis?
Population
9 postmenopausal women with advanced rheumatoid arthritis requiring unilateral sialastic implant…
Comparison
Intraarticular injection of autologous synovial… vs Intraarticular injection of untransduced…
Design
Other, double-blinded
Follow-up
1 week
Authors
Discussion
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Member takes
Implication
Supports feasibility of IL-1Ra gene transfer in RA joints without short-term harm; leaves open efficacy in larger trials.
Structured PICO
Does intraarticular transfer of IL-1Ra cDNA safely result in transgene expression in postmenopausal women with advanced rheumatoid arthritis?
P
Population
9 postmenopausal women with advanced rheumatoid arthritis (RA) requiring unilateral sialastic implant arthroplasty of the 2nd-5th metacarpophalangeal (MCP) joints
I
Intervention
Intraarticular injection of autologous synovial fibroblasts transduced with a retrovirus carrying IL-1Ra cDNA
C
Comparator
Intraarticular injection of untransduced, control autologous synovial fibroblasts
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Outcome
Evidence of successful gene transfer and expression (measured by RT-PCR, ex vivo production of IL-1Ra, in situ hybridization, and immunohistochemistry) and safetysurrogate
Intraarticular transfer of the IL-1Ra gene using retrovirally transduced autologous fibroblasts is safe and results in successful transgene expression in human rheumatoid joints.
Cite This Study
Evans et al. (2005) studied this question.