Why the study?
Does adenoviral mediated delivery of FAS ligand cause apoptosis in synovial fibroblasts and arthritic joints?
Does adenoviral mediated delivery of FAS ligand cause apoptosis in synovial fibroblasts and arthritic joints?
Adenoviral delivery of FAS ligand induces significant apoptosis in synovial fibroblasts and arthritic joints, suggesting a potential targeted approach for arthritis.
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Ad.FasL induces synovial apoptosis without chondrocyte toxicity in animals; leaves open therapeutic translation to human arthritis.
Yao et al. (2000) studied this question.
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