Why the study?
Does anti-Fas antibody induce apoptosis in rheumatoid arthritis synoviocytes?
Population
Rheumatoid arthritis (RA) synovial cells (synoviocytes)
Design
Preclinical
Authors
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Suggests Fas as a target to limit RA synovial hyperplasia; hypothesis-generating and should not yet change practice.
Does anti-Fas antibody induce apoptosis in rheumatoid arthritis synoviocytes?
This study provides the first evidence that rheumatoid synoviocytes undergo Fas-mediated apoptosis, suggesting a potential mechanism for regulating synovial cell proliferation in RA.
Nakajima et al. (1995) studied this question.
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