October 15, 1997Journal of Clinical InvestigationOpen Access

Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer.

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Why the study?

Does FasL gene transfer ameliorate collagen-induced arthritis in DBA/1 mice?

Population

DBA/1 mice with collagen-induced arthritis

Comparison

Recombinant replication-defective adenovirus… vs Coadministration of Fas-immunoglobulin fusion…

Design

Preclinical

Authors

HZH ZhangUniversity of Pennsylvania YYYa‐Wen YangNational Taiwan University Hospital JHJennifer L. HortonUniversity of Pennsylvania

Discussion

Member takes

Implication

Hypothesis-generating for FasL gene therapy in arthritis; human trials needed before clinical translation.

Structured PICO

Does FasL gene transfer ameliorate collagen-induced arthritis in DBA/1 mice?

Population

DBA/1 mice with collagen-induced arthritis

Intervention

Recombinant replication-defective adenovirus carrying FasL gene injected into inflamed joints

Comparator

Coadministration of Fas-immunoglobulin fusion protein with the Fas-ligand virus

Outcome

Amelioration of collagen-induced arthritissurrogate

FasL gene transfer at the site of inflammation effectively ameliorates autoimmune disease in a mouse model of arthritis.

Cite This Study

Zhang et al. (1997) studied this question.

synapsesocial.com/papers/6a7db08329cd345315cda316 https://doi.org/10.1172/jci119726

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Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider