Why the study?
Does intra-articular administration of anti-Fas mAb improve arthritis in HTLV-1 tax transgenic mice?
Population
HTLV-1 tax transgenic mice (animal model of rheumatoid arthritis)
Design
Preclinical
Follow-up
48 h
Authors
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Hypothesis-generating for local Fas targeting in proliferative synovitis; leaves open translation and safety in human rheumatoid arthritis.
Does intra-articular administration of anti-Fas mAb improve arthritis in HTLV-1 tax transgenic mice?
Local administration of anti-Fas mAb induces apoptosis in synovial cells and improves arthritis in a transgenic mouse model, suggesting a potential therapeutic strategy for proliferative synovitis such as rheumatoid arthritis.
Fujisawa et al. (1996) studied this question.
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