DFNA11 presents as the mildest phenotype among MYO7A mutations, characterized by moderate, gradually progressive postlingual sensorineural hearing loss without retinal degeneration.
May inform prognosis in MYO7A-related hearing loss; extends observational genotype-phenotype data but leaves validation open.
The phenotype of DFNA11 is postlingual, nonsyndromic sensorineural hearing loss with gradual progression. Showing moderate hearing loss with asymptomatic variable vestibular dysfunction and no retinal degeneration, the DFNA11 phenotype is mildest among phenotypes caused by MYO7A mutations.
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Tamagawa et al. (2002) studied this question.
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