July 7, 2010Open Access

Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

AHAsimina HionaUniversity of Wisconsin–Madison ASAlberto SanzThe University of Melbourne GKGregory C. KujothUniversity of Wisconsin–Madison

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Abstract

These findings demonstrate that mutations in mtDNA can be causal in sarcopenia by affecting the assembly of functional ETC complexes, the lack of which provokes a decrease in oxidative phosphorylation, without an increase in oxidative stress, and ultimately, skeletal muscle apoptosis and sarcopenia.

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