Key result
Higher TyG index is linked to increased cardiovascular disease and all-cause mortality in type 1 diabetes.
Why the study?
Does a higher TyG index predict increased risk of all-cause mortality and cardiovascular disease in adults with type 1 diabetes?
Cohort
Does a higher TyG index predict increased risk of all-cause mortality and cardiovascular disease in adults with type 1 diabetes?
The TyG index could serve as a simple, non-invasive marker to identify adults with type 1 diabetes at high risk for cardiovascular disease and mortality.
What is currently known about this topic? 1. The TyG index is associated with insulin resistance and cardiovascular disease in both patients with type 2 diabetes and the general population. What is the key research question? 1. Could the TyG index also be utilized to assess insulin resistance and cardiovascular disease risk in patients with type 1 diabetes? What is new? 1. In patients with type 1 diabetes, those in the higher TyG quartile showed a higher prevalence of metabolic dysfunction such as obesity, hypertension and dyslipidemia. 2. A higher TyG index in patients with type 1 diabetes was associated with an increased risk of all-cause mortality and cardiovascular disease including myocardial infarction, heart failure and stroke. How might this study influence clinical practice? 1. The TyG index, a simple and non-invasive marker composed of triglycerides and fasting glucose, could be used to identify patients with type 1 diabetes who have high insulin resistance and cardiovascular disease risk.
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Oh et al. (2025) conducted a cohort in Type 1 diabetes. Elevated triglyceride-glucose (TyG) index vs. Lower TyG index was evaluated on All-cause mortality and cardiovascular disease (including myocardial infarction, heart failure, and stroke). A higher triglyceride-glucose index in adults with type 1 diabetes was associated with an increased risk of all-cause mortality and cardiovascular disease.
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