Experimental study demonstrates that AQP4 inhibition with TGN-020 reduces edema and astrogliosis after cerebral ischemia, indicating a potential neuroprotective strategy for acute stroke.
We found that acutely inhibiting AQP4 using TGN-020 promoted neurological recovery by diminishing brain edema at the early stage and attenuating peri-infarct astrogliosis and AQP4 depolarization at the subacute stage after stroke. Moreover, ADCuh could reflect the AQP4 polarization.
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Sun et al. (2022) studied this question.
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