May 1, 2002The Journals of Gerontology Series A
Relationship of Interleukin-6 and Tumor Necrosis Factor- With Muscle Mass and Muscle Strength in Elderly Men and Women: The Health ABC Study
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Discussion
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Implication
Cohort study reveals elevated IL-6 and TNF-alpha levels correlate with reduced muscle mass and strength in older adults, suggesting chronic inflammation drives age-related muscle loss.
Key Points
- Determine how circulating concentrations of inflammatory cytokines, specifically IL-6 and TNF-alpha, relate to muscle mass and muscle strength in older adults.
- Measured plasma concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in well-functioning older men and women from the Health ABC Study.
- Evaluated the association between inflammatory cytokine levels and measures of muscle mass and muscle strength.
- Higher plasma concentrations of IL-6 and TNF-alpha were qualitatively associated with lower overall muscle mass in well-functioning older adults.
- Elevated levels of both cytokines were associated with significantly lower muscle strength in both elderly men and women.
Cite This Study
Visser et al. (2002) studied this question.