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Animal study reveals increased VEGF expression without reduced osteonecrosis in rabbits given prophylactic tadalafil, suggesting limited preventive efficacy.
This study has shown us that femoral head osteonecrosis can be reliably induced with LPS and corticosteroid, as described in the literature. Prophylactic tadalafil use did not decrease the occurrence of osteonecrosis significantly. However, it significantly increased VEGF expression in the femoral head independent of the effects of steroids and LPS.
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Özmen et al. (2023) studied this question.
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