What question did this study set out to answer?

To assess the physiological effects of VEGF-augmented vascularity on resting and stimulated blood flow in an animal model of hindlimb ischemia.

October 1, 1994AJP Heart and Circulatory Physiology

Physiological assessment of augmented vascularity induced by VEGF in ischemic rabbit hindlimb

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Authors

CBChristophe BautersInterventional Cardiology TATakayuki AsaharaTokai University LZLiangliang ZhengNanchang University

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Implication

Controlled animal study demonstrates that intra-arterial VEGF enhances blood flow velocity in ischemic hindlimbs, suggesting therapeutic utility for lower extremity ischemia.

Key Points

To assess the physiological effects of VEGF-augmented vascularity on resting and stimulated blood flow in an animal model of hindlimb ischemia.
Surgical excision of the common and superficial femoral arteries was performed on one hindlimb of 24 New Zealand White rabbits to induce ischemia.
Ten days post-surgery, rabbits received selective intra-arterial injections of either VEGF (n = 15) or saline control (n = 9) via the ipsilateral internal iliac artery.
Perfusion and blood flow velocity were measured at baseline, day 10, and day 30 using a Doppler guide wire under resting conditions and papaverine-provoked maximal flow.
No significant differences in resting or stimulated blood flow velocity were observed between the control and VEGF-treated groups at baseline or day 10.
By day 30, the VEGF-treated group exhibited significantly higher resting flow (P < 0.05), maximum flow velocity (P < 0.001), and maximum blood flow (P < 0.001) compared to controls.

Cite This Study

Bauters et al. (1994) studied this question.

synapsesocial.com/papers/6a7ef012b17cd61547d0a763 https://doi.org/10.1152/ajpheart.1994.267.4.h1263

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Implication

Controlled animal study demonstrates that intra-arterial VEGF enhances blood flow velocity in ischemic hindlimbs, suggesting therapeutic utility for lower extremity ischemia.

Physiological assessment of augmented vascularity induced by VEGF in ischemic rabbit hindlimb

Discussion

Member takes

Implication

Key Points

Cite This Study

Physiological assessment of augmented vascularity induced by VEGF in ischemic rabbit hindlimb

Discussion

Member takes

Implication

Key Points

Cite This Study

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