A Qc Approach to The Determination of Day-To-Day Reproducibility And Robustness of Lc–Ms Methods For Global Metabolite Profiling in Metabonomics/Metabolomics

The day-to-day variability of the data revealed by this process suggested that, for this particular system, 3 days continuous operation was possible without the need for maintenance and cleaning. Variation was generally based on signal intensity changes over the 7-day period of the study, and was mainly a result of source contamination.