Background: Gonadotropin free -subunit (FAS) levels paradoxically increase during GnRH agonist (GnRHa) treatment of central precocious puberty (CPP). The histrelin implant suppresses gonadotropins and estradiol (E 2 ) levels for 1 yr, but effects on FAS have not been described.
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Hirsch et al. (2010) studied this question.
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