Why the study?
Abdominal adiposity may trigger causal pathological processes leading to cerebrovascular disease, and identifying targets of these processes could represent novel therapeutic opportunities for stroke.
Does abdominal adiposity causally increase the risk of cerebrovascular disease?
Does abdominal adiposity causally increase the risk of cerebrovascular disease?
Abdominal adiposity is causally linked to cerebrovascular disease through pathways partially independent of blood pressure and independent of glucose levels, suggesting novel therapeutic targets for stroke.
Abdominal adiposity reduction may offer cerebrovascular benefits independent of BP and glucose; extends causal MR evidence but leaves interventional confirmation needed.
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Marini et al. (2020) studied this question.
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