What question did this study set out to answer?

To review redox-related mechanisms regulating pancreatic beta cell dysfunction and death in type 1 and type 2 diabetes, while evaluating antioxidant and epigenetic therapeutic interventions.

September 23, 2022SHILAP Revista de lepidopterologíaOpen Access

Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management

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Authors

SDSvetlana DinićUniversity of Belgrade JЈJelena Arambašić ЈovanovićUniversity of Belgrade AUAleksandra UskokovićUniversity of Belgrade

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Implication

Review uncovers redox-driven beta cell death mechanisms in diabetes, highlighting the therapeutic potential of antioxidants and CRISPR/Cas9 epigenome editing.

Key Points

To review redox-related mechanisms regulating pancreatic beta cell dysfunction and death in type 1 and type 2 diabetes, while evaluating antioxidant and epigenetic therapeutic interventions.
Synthesized molecular mechanisms of free radical damage, glucotoxicity, and loss of developmental transcription factors across type 1 and type 2 diabetes.
Assessed experimental evidence regarding protective natural antioxidants and epigenetic therapies, with a specific focus on CRISPR/Cas9-based targeted epigenome editing.
Oxidative stress triggers autoimmune beta cell loss in type 1 diabetes and drives dedifferentiation, transdifferentiation, and cell death in type 2 diabetes.
Natural antioxidants counteract oxidative damage and support the preservation of insulin-secreting beta cell populations.
CRISPR/Cas9 epigenome editing successfully alters the differentiation state of alternative cell types into functional insulin-producing cells.

Cite This Study

Dinić et al. (2022) studied this question.

synapsesocial.com/papers/69deaaf1210a0977fce95112 https://doi.org/10.3389/fendo.2022.1006376

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Implication

Review uncovers redox-driven beta cell death mechanisms in diabetes, highlighting the therapeutic potential of antioxidants and CRISPR/Cas9 epigenome editing.

Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management

Discussion

Member takes

Implication

Key Points

Cite This Study

Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management

Discussion

Member takes

Implication

Key Points

Cite This Study

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