Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

Xiangyu Ge; Mojca Frank‐Bertoncelj; Kerstin Klein; Amanda McGovern; Tadeja Kuret; Miranda Houtman; Blaž Burja; Raphael Micheroli; Chenfu Shi; Miriam Marks; Andrew Filer; Christopher D. Buckley; Gisela Orozco; Oliver Distler; Andrew P. Morris; Paul Martin; Stephen Eyre; Caroline Ospelt

doi:10.1186/s13059-021-02460-6

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Abstract

Overall, our research provides the first direct evidence for a causal role of FLS in the genetic susceptibility for RA accounting for up to a quarter of RA heritability.

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Ge et al. (2021) studied this question.

synapsesocial.com/papers/69deab147702a00918b0c5e2 https://doi.org/10.1186/s13059-021-02460-6

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Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

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Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

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