What question did this study set out to answer?

To assess the association between adjuvant chemotherapy and overall survival among older adults diagnosed with stage II colon cancer, stratified by the presence of poor prognostic features.

July 26, 2011Journal of Clinical Oncology

Adjuvant Chemotherapy for Stage II Colon Cancer With Poor Prognostic Features

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Authors

EOErin S. O’ConnorUniversity of Toronto DGDavid Yü GreenblattSharp Rees-Stealy Medical Group NLNoelle K. LoConteUniversity of Wisconsin–Madison

Discussion

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Implication

Cohort study finds adjuvant chemotherapy fails to improve overall survival in older adults with stage II colon cancer, indicating routine use may not benefit this population.

Key Points

To assess the association between adjuvant chemotherapy and overall survival among older adults diagnosed with stage II colon cancer, stratified by the presence of poor prognostic features.
Analyzed Medicare beneficiaries diagnosed with stage II colon cancer.
Evaluated overall survival associated with adjuvant chemotherapy administration in subsets with and without poor prognostic features.
Adjuvant chemotherapy did not substantially improve overall survival in patients with stage II colon cancer, regardless of poor prognostic feature status.
Treatment strategies for older adults require reassessment given the lack of demonstrable survival benefit from chemotherapy.

Cite This Study

O’Connor et al. (2011) studied this question.

synapsesocial.com/papers/69deab616bae133e7de948fe https://doi.org/10.1200/jco.2010.34.3426

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Implication

Cohort study finds adjuvant chemotherapy fails to improve overall survival in older adults with stage II colon cancer, indicating routine use may not benefit this population.

Adjuvant Chemotherapy for Stage II Colon Cancer With Poor Prognostic Features

Discussion

Member takes

Implication

Key Points

Cite This Study

Adjuvant Chemotherapy for Stage II Colon Cancer With Poor Prognostic Features

Discussion

Member takes

Implication

Key Points

Cite This Study

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