What question did this study set out to answer?

To delineate the clinical syndrome of frailty in aging individuals, distinguish it from general disability, and examine its underlying pathophysiological mechanisms and adverse health consequences.

January 1, 2008Annals of Nutrition and Metabolism

Aging, Disability and Frailty

View Full Paper

Ask AI

Bookmark

To delineate the clinical syndrome of frailty in aging individuals, distinguish it from general disability, and examine its underlying pathophysiological mechanisms and adverse health consequences.
Reviewed clinical and epidemiological frameworks defining frailty and distinguishing it from functional disability in older adults.
Synthesized evidence evaluating physical phenotype characteristics, preclinical conditions, and laboratory biomarkers related to multisystem physiological dysregulation.
Frailty affects 20% to 30% of adults older than 75 years, with prevalence rising with advancing age.
The syndrome manifests as low activity, exhaustion, muscle weakness, slow gait, and weight loss, significantly raising risks for hospital admission, institutional placement, and mortality.
Clinical frailty is linked to preclinical sarcopenia and osteopenia, as well as elevated IL-6, CRP, and D-dimers alongside altered IGF-1 and 25-hydroxyvitamin D levels.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Narrative review demonstrates multi-system decline and inflammatory biomarker links in frail older adults, highlighting the distinct clinical risks of geriatric frailty.

Cite This Study

Eva Topinková (2008) studied this question.

synapsesocial.com/papers/69deab944838c5c0bab0ca99 https://doi.org/10.1159/000115340

View Full Paper

Ask AI

Bookmark

Implication

Narrative review demonstrates multi-system decline and inflammatory biomarker links in frail older adults, highlighting the distinct clinical risks of geriatric frailty.

Aging, Disability and Frailty

Key Points

Discussion

Implication

Cite This Study

Aging, Disability and Frailty

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider