Why the study?
Major systemic manifestations in COVID-19 indicate that the virus targets the endothelium, prompting a comprehensive evaluation of supporting clinical and preclinical evidence.
Design
Systematic evaluation of clinical and preclinical evidence
Authors
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Endothelial involvement merits clinical consideration in COVID-19 complications; confirms mechanistic basis for multi-organ effects.
This systematic evaluation provides a mechanistic rationale for COVID-19 as an endothelial disease, explaining systemic manifestations like thrombosis and hypertension.
Sardu et al. (2020) studied this question.
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