What question did this study set out to answer?

To develop a multi-enzyme integrated nanoplatform that remodels the tumor microenvironment and enables synergistic photodynamic, photothermal, and chemodynamic antitumor therapy.

April 29, 2025Colloids and Surfaces B BiointerfacesOpen Access

A CuS/Ag/Pt@ICG/DOX nanoplatform with cascaded nanozyme catalysis for tumor microenvironment remodeling and synergistic photodynamic/photothermal/chemodynamic therapy

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Authors

WZWenqi Zhu DCDong Cheng LLLinsong Li

Discussion

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Overview

Preclinical evaluation demonstrates 88.9% tumor inhibition using a catalytic nanoplatform, highlighting a synergistic strategy for multimodal cancer therapy.

Key Points

To develop a multi-enzyme integrated nanoplatform that remodels the tumor microenvironment and enables synergistic photodynamic, photothermal, and chemodynamic antitumor therapy.
Engineered a hierarchically structured platform (CAPID) by depositing dual-enzyme-active silver and platinum onto copper sulfide nanoparticles.
Loaded the nanoparticles with indocyanine green as a near-infrared fluorophore and doxorubicin as a chemotherapeutic agent.
Assessed catalytic cascade activity, including catalase-mediated hydrogen peroxide decomposition, copper-driven glutathione depletion, and near-infrared-triggered tri-therapy synergy.
The catalytic cascade converted endogenous hydrogen peroxide to oxygen to relieve hypoxia and initiated Fenton-like reactions producing cytotoxic hydroxyl radicals.
Redox cycling between copper ions and intracellular thiols depleted glutathione, amplifying oxidative stress cascades within the tumor microenvironment.
Near-infrared irradiation enabled combined chemo-, photodynamic, and photothermal therapy, achieving 88.9% tumor inhibition.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/69deac43499d77a496b0c6df https://doi.org/10.1016/j.colsurfb.2025.114743

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April 29, 2025Colloids and Surfaces B BiointerfacesOpen Access

A CuS/Ag/Pt@ICG/DOX nanoplatform with cascaded nanozyme catalysis for tumor microenvironment remodeling and synergistic photodynamic/photothermal/chemodynamic therapy

View Full Paper

Ask AI

Bookmark

Authors

WZWenqi Zhu DCDong Cheng LLLinsong Li

Discussion

Member takes

Overview

Preclinical evaluation demonstrates 88.9% tumor inhibition using a catalytic nanoplatform, highlighting a synergistic strategy for multimodal cancer therapy.

Key Points

To develop a multi-enzyme integrated nanoplatform that remodels the tumor microenvironment and enables synergistic photodynamic, photothermal, and chemodynamic antitumor therapy.
Engineered a hierarchically structured platform (CAPID) by depositing dual-enzyme-active silver and platinum onto copper sulfide nanoparticles.
Loaded the nanoparticles with indocyanine green as a near-infrared fluorophore and doxorubicin as a chemotherapeutic agent.
Assessed catalytic cascade activity, including catalase-mediated hydrogen peroxide decomposition, copper-driven glutathione depletion, and near-infrared-triggered tri-therapy synergy.
The catalytic cascade converted endogenous hydrogen peroxide to oxygen to relieve hypoxia and initiated Fenton-like reactions producing cytotoxic hydroxyl radicals.
Redox cycling between copper ions and intracellular thiols depleted glutathione, amplifying oxidative stress cascades within the tumor microenvironment.
Near-infrared irradiation enabled combined chemo-, photodynamic, and photothermal therapy, achieving 88.9% tumor inhibition.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/69deac43499d77a496b0c6df https://doi.org/10.1016/j.colsurfb.2025.114743

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