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January 14, 2019Cardiovascular ToxicologyOpen Access

Carnitine Supplementation Attenuates Sunitinib-Induced Inhibition of AMP-Activated Protein Kinase Downstream Signals in Cardiac Tissues

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Why the study?

To investigate whether sunitinib alters cardiac mitochondrial transport and oxidation of long-chain fatty acids as a mechanism of cardiotoxicity, and whether carnitine supplementation attenuates this cardiotoxicity.

Does L-carnitine supplementation prevent sunitinib-induced cardiotoxicity in adult male Wister albino rats?

Population

Adult male Wister albino rats

Comparison

Sunitinib, L-carnitine, both combined, or untreated control

Design

Preclinical randomized animal study

Follow-up

28 days

Authors

MSMohamed M. Sayed‐AhmedCairo UniversityBABadr I. AlrufaiqAAAmmar C. Al‐RikabiKing Saud University

Discussion

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Overview

L-carnitine should not yet alter sunitinib management in patients; leaves open translation of rat cardioprotection to clinical TKI use.

Structured PICO

Does L-carnitine supplementation prevent sunitinib-induced cardiotoxicity in adult male Wister albino rats?

P
Population
Adult male Wister albino rats
I
Intervention
L-carnitine (200 mg/kg/day) and sunitinib (25 mg/kg/day) in drinking water for 28 days
C
Comparator
Sunitinib alone (25 mg/kg/day), L-carnitine alone (200 mg/kg/day), or no treatment (free access to tap water) for 28 days
O
Outcome
Biochemical, gene expression (AMPKα2, CPT I, ACC2), and histopathological changes in cardiac tissuessurrogate

In a rat model, L-carnitine supplementation completely reversed sunitinib-induced cardiotoxicity and restored AMPK downstream signaling.

Cite This Study

Sayed‐Ahmed et al. (2019) studied this question.

synapsesocial.com/papers/69deb3b740ea065679559282https://doi.org/10.1007/s12012-018-9500-0
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