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June 29, 2005Physiological ReviewsOpen Access

Myocardial Substrate Metabolism in the Normal and Failing Heart

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Population

Normal and failing hearts (chronic heart failure)

Design

Review

Authors

WSWilliam C. StanleyGeneral CardiologyFRFabio A. RecchiaHeart Failure & TransplantGary D. LopaschukGary D. LopaschukHeart Failure & Transplant

Discussion

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Implication

Metabolic shifts in advanced HF identify potential targets; leaves open whether modulating them alters outcomes in trials.

Structured PICO

P
Population
Normal and failing hearts (chronic heart failure)

This review highlights that while myocardial substrate selection is relatively normal in early heart failure, advanced stages are characterized by significant metabolic shifts including downregulated fatty acid oxidation and increased glycolysis, which may serve as therapeutic targets.

Cite This Study

Stanley et al. (2005) studied this question.

synapsesocial.com/papers/69d6fc7339aaaf0da5ab3a56https://doi.org/10.1152/physrev.00006.2004

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ventricular Remodeling Does Not Accompany the Development of Heart Failure in Diabetic Patients After Myocardial Infarction2002 · 104 citations
  2. 2Partial fatty acid oxidation inhibitors for stable angina2002 · 62 citations
  3. 3Partial Fatty Acid Oxidation Inhibitors: A Potentially New Class of Drugs for Heart Failure2002 · 23 citations
  4. 4Regulation of Malonyl-CoA Concentration and Turnover in the Normal Heart2004 · 43 citations