January 17, 2012European Journal of Heart Failure

Targeting Myocardial Substrate Metabolism in Heart Failure: Potential for New Therapies

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Population

Patients with heart failure

Design

Review

Authors

HAHossein ArdehaliUniversity of Arizona HSHani N. SabbahHeart Failure & Transplant MBMichael A. BurkeHeart Failure & Transplant

Discussion

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Implication

Cardiac energetics modulation remains investigational in heart failure; leaves open whether substrate shifts improve outcomes.

Structured PICO

Population

Patients with heart failure

Intervention

Targeting myocardial substrate metabolism (fatty acid and glucose metabolism, AMP-activated kinase)

This review emphasizes the potential of targeting altered myocardial substrate metabolism, such as fatty acid and glucose pathways, as a novel therapeutic strategy for heart failure.

Cite This Study

Ardehali et al. (2012) studied this question.

synapsesocial.com/papers/6a72b17e2163a0a01bc63ee5 https://doi.org/10.1093/eurjhf/hfr173

Topics

Heart failure HFrEF treatment HFpEF management

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Targeting Myocardial Substrate Metabolism in Heart Failure: Potential for New Therapies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Targeting Myocardial Substrate Metabolism in Heart Failure: Potential for New Therapies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider